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When combined with daily lifestyle modifications (timed urination, pelvic floor exercises and fluid management), patients saw a reduction of the OAB symptom of urinary accidents by 75% vs.

Novara G, Galfano A, Secco S et al: A systematic review and meta-analysis of randomized controlled trials with antimuscarinic drugs for overactive bladder.

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Diaries that document intake and voiding behavior may be useful in some patients, particularly the patient who cannot describe or who is not familiar with intake and voiding patterns.

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Oxybutynin topical (for the skin) is used to treat symptoms of overactive bladder such as frequent or urgent urination, and incontinence (urine leakage).

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Hashim H and Abrams P: How should patients with an overactive bladder manipulate their fluid intake?

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There is no literature that addresses combination therapy of anti-muscarinics with each other, the combination of the anti-muscarinics with β3-adrenoceptor agonists, or the combination of anti-muscarinics with other classes of medication such as tricyclics to manage non-neurogenic OAB.

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Choo MS, Ku JH, Lee JB et al: Cross-cultural differences for adapting overactive bladder symptoms: results of an epidemiologic survey in Korea.

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Hot flashes and night sweats are common side effects while on the medication, and resolve upon discontinuation of the medication.

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