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Their therapeutic uses derive from their tendency to reduce in the liver, and, as a result, reduce the level of glucose in the blood.
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Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes.
Use of Automated Bolus Calculators for Diabetes Management.
Jonsson A, Chan JC, Rydberg T, Vaaler S, Hallengren B, Cockram CS, Critchley JA, Melander A: Pharmacodynamics and pharmacokinetics of intravenous glibenclamide in Caucasian and Chinese patients with type-2 diabetes.
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For example, the combined administration comprises administering a dosage formulation comprising both metformin and mitiglinide only once per day.
The maximum recommended daily dose of Metformin is 2550 mg for adults and 2000 mg for pediatric patients (10 to 16 years of age).
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Chromium supplementation has been found helpful for still other types of diabetes.
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When presented with the results of his examination, Dwayne admits to having a sedentary lifestyle; frequent consumption of fried, fatty foods and soft drinks; infrequent consumption of fruits and vegetables; and frequent snacking.
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Teratogenicity and embryo-lethality occurred in animals administered leflunomide at doses lower than the human exposure level.
Children with biopsy-confirmed celiac disease should be placed on a gluten-free diet and have consultation with a dietitian experienced in managing both diabetes and celiac disease.
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However, such combinations have been found to provide no additional cardiovascular benefit and have higher adverse event rates ().
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DRUG INTERACTIONS: The effects of some can change if you take other drugs or herbal products at the same time.
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New research suggests that several commonly prescribed drugs for type 2 diabetes may not be as effective at preventing death and cardiovascular diseases, such as heart attacks and stroke, as the oral anti-diabetic drug, metformin.
Consult drug interactions database for more detailed information.
However, given that CYP2C8 plays only a minor role in the metabolism of these substrates, it is unlikely that CYP2C8 polymorphisms would have clinically relevant effects for these particular drugs.
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Because animal reproduction studies are not always predictive of human response, Repaglinide should be used during pregnancy only if it is clearly needed.
Pregnancy as a Window to Future Cardiovascular Health: Design and Implementation of the nuMoM2b Heart Health Study.
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The incretin, glucagon-like peptide (GLP)-1, released from the small intestine after eating, enhances insulin responses to glucose, as well as suppressing glucagon postprandially.
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Although many combinations are not yet approved for use, a rational choice for combination therapy would include an agent that increases insulin levels and one that enhances sensitivity to insulin and lowers glucose production.
You should wait at least seven years from the date of release to take any new drug unless it is one of those rare “breakthrough” drugs that offers you a documented therapeutic advantage over older proven drugs.
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Find out how using a combination of two drugs, one from each of these two families, can increase the risks of kidney toxicity and dangerously higher blood levels of potassium compared to use of one of these two families of drugs alone.
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The ADA recommends that selected patients, especially those with a long life expectancy and little comorbidity, adopt glycemic targets close to normal, providing the target can be achieved without significant hypoglycemia.
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